The evaluation of spectrophotometric method used for measuring of the contents of mebendazole in 5 Helmivet in powder

Stankovic-Nesic, N.; Marinkovic, V.; Gudzic, B.; Stojanovic, Z.

The evaluation of spectrophotometric method used for measuring of the contents of mebendazole in 5 Helmivet in powder

1997

Stankovic-Nesic, N. | Marinkovic, V. | Gudzic, B. | Stojanovic, Z. (Fabrika farmaceutskih i hemijskih proizvoda D.D. "Zdravlje", Leskovac (Yugoslavia))

Mebendazole is anthelmintic with wide range of effects. Spectrophotometric method for analysing of mebendazole in Helmivet powder is testing to: selectivity, precision, linearity, accuracy, sensitivity and stability. The testing solution shows the absorptive maximum (peak) at L=262 nm. The average value of mebendazole contents is 49.8 mg/g. The coefficient of variation is 1.11, and "recovery" value for laboratory sample is 101.8 - 105 the limits of detection and quantification are 2.9 x 10E-4 mg/ml and 1.5 x 10E-3 mg/ml. The linear dependence of absorption and concentration on a scale of 2.5 x 10E-3 was found. The parameters of validation prove that the suggested spectrophotometric method can be used for quantitative analysis of mebendazole in dosed forms.

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AGROVOC Keywords

anthelminthique anthelmintics benzimidazole benzimidazoles espectrometria spectrometrie spectrometry

Bibliographic information

Publisher

Jugoslovensko udruzenje strucnjaka iz oblasti proizvodnje, ispitivanja, kontrole i prometa lekova za upotrebu u veterini

Pagination

p. 187-188

Other Subjects

Antihelminticos

Language

Serbian

Note

Summary (En)

3 ref. Text in cyrillic.

Translated Title

Validacija spektrofotometrijske metode za odredjivanje sadrzaja mebendazola u 5-nom prahu Helmiveta

Type

Summary; Conference

Source

Proceedings of the 3rd conference on drugs for veterinary use, Igalo [Yugoslavia], April 14-18, 1997, Zivanov, D. (ed.).- Beograd (Yugoslavia): Jugoslovensko udruzenje strucnjaka iz oblasti proizvodnje, ispitivanja, kontrole i prometa lekova za upotrebu u veterini, 1997

Conference

3. savetovanje o lekovima za upotrebu u veterini, Igalo (Yugoslavia), 14-18 Apr 1997

In AGRIS since: 1998-08-15

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