Laboratory evaluation of the anti-inflammatory effect of prednisolone using the "inflammation model"
1997
Kondic-Kaurin, S. | Pitic, Lj. (ICN Jugoslavija - Galenika, Beograd (Yugoslavia). Sektor kontrole kvaliteta)
To evaluate the antiinflammatory effect of prednisolone an "inflammation model" caused by the phlogistic agent - carrageenin - was used. The inflammatory process develops as early as one hour after the application of carrageenin, as edema of the hing paw of the Wistar rat (n = 100), reaching a maximum after six hours. Oral prednisolone, administered one hour before carrageenin reduces edema by 25 at six hours, thus fulfilling the criteria for a positive evaluation of its antiinflammatory effect.
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