Granulopoiesis during acute Toxoplasma gondii infection in mice
1997
Jovcic, G. | Petakov, M. | Bugarski, D. | Djurkoviv-Djakovic, O. | Kragujevic, A. | Stojanovic, N. (Institute for Medical Research, Belgrade (Yugoslavia))
The data obtained revealed that granulocytic cells at various stages of differentiation and maturation were affected by Toxoplasma gondii infection regardless of the dose applied. The observed oscillating changes in the number of cells in granulocytic proliferative and nonproliferative compartments imply that parallel with Toxoplasma gondii-induced damage to granulocytic cells, a process of stimulated production of granulocytes occurred. Although some differences in the kinetics of cellular changes and in the extent of cell damage were found, similar reactivity patterns of granulocytic cells were seen following infection with both doses. The results demonstated significant changes in granulopoiesis during Toxoplasma gondii infection, suggesting a possible contribution of granulocytes to parasite control.
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