Examination of immunogenicity of experimental subunit vaccines against PI3 [parainfluenza 3] virus in calves
1998
Milic, N. | Gadjanski-Omerovic, G. | Asanin, R. (Faculty of Veterinary Medicine, Belgrade (Yugoslavia))
The objective of the study was to check the immunogenicity of experimental subunit vaccines against PI3 (parainfluenza 3) virus in a biological assay on 30 experimental calves of the Yugoslav Simmental breed, aged 5-6 months, of body weight 200-230 kg. One experimental vaccine was prepared from purified glycoprotein subunits, isolated from the outer envelope of the SD2 strain of the PI3 (parainfluenza 3) virus; wherease the other subunit vaccine was prepared from purified glycoprotein antigens, isolated from the external envelope of the Yugoslav strain of the virus. Antigens of these vaccines with haeagglutinating titres of 128 HJ/0.1 ml, were adsorbed on the adjuvant - Al(OH)3, dissolved at 100 mmol/l PBS. The final concentration of the adjuvant in the vaccines was 5 mg/ml. These experimantal subunit vaccines against the PI3 (parainfluenza 3) virus with low concentrations of the glycoprotein antigens, i.e. 0.30 mg per dose, induced a satisfactory humoral immune response in the organisms of all vaccinated animals.
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