Levamisole modulates experimental autoimmune encephalomyelitis (EAE) in DA rats
2001
Ilic, V. (Faculty of Veterinary Medicine, Belgrade (Yugoslavia)) | Lazarevic, M. | Rauski, A. | Popovic, N. | Kosec, D.
The obtained results indicate that in autoimmune encephalomyelitis (EAE) an antiparasitic drug, levamisole exerts immunosuppressive effects when administered every other day from the moment of immunization until the end of the disease. This application regime and dose postponed the onset of the first clinical signs, shortened the duration of the disease, abrogated the severity of clinical symptoms and accelerated the recovery of sick animals. In the period of induction and during EAE, levamisole also decreased the severity of changes in the cerebral perivascular spaces. In the peripheral blood of levamisole treated animals with induced EAE, a significant increase of CD4-CD8+ T cells was demonstrated. Furthermore, all rats with induced EAE had decreased numbers of CD4+CD8- T cells in their blood. These changes were in correlation with clinical signs of EAE.
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