EXPRESSION OF ONCOMARKER PROTEINS IN MAMMARY GLAND TUMOR CELLS IN CATS | ЭКСПРЕССИЯ ОНКОМАРКЕРНЫХ БЕЛКОВ В ОПУХОЛЕВЫХ КЛЕТКАХ МОЛОЧНЫХ ЖЕЛЕЗ У КОШЕК
2023
V. V. Mitenko | O. V. Dilekova | В. В. Митенко | О. В. Дилекова
At the present stage of the study of carcinogenesis, the main mechanism of genetically determined changes leading to uncontrolled cell malignancy is based on molecular research. The greatest interest is given to the study of proteins included in the region of nucleolar organizers (Ag-NROR-proteins) and supporting the biogenesis and transcription of ribosomes. The main biomarkers are: nucleolin/NCL (the phosphoprotein involved in the processing step), nucleophosmin/B23 (the family of non-histone proteins that maintain genome stability), fibrillarin/FBL (the main regulator of several stages of ribosome biogenesis). In the presented work, nucleolar chaperones were studied: nucleolin/NCL, nucleophosmin/B 23, fibrillarin/FBL in mammary gland tumor cells in cats (n = 16). The review considers the results of an immunohistochemical study, which revealed the production of these proteins and their localization in cells. During the study, it was revealed that the location of NCL, B23 and FBL is nucleolar and nuclear, from moderate (+2) to intense (+3). In addition, the localization of NCL was visualized in the cytoplasm of cells, which characterizes this biomarker as a chaperone for protein transfer. The studied transcription proteins lead to chromosomal aberrations inside cells, and, as a consequence, to malignant transformation
Show more [+] Less [-]Bibliographic information
This bibliographic record has been provided by Don State Technical University