Emerging issues in probiotic safety: 2023 perspectives
2023
Merenstein, Daniel | Pot, Bruno | Leyer, Gregory | Ouwehand, Arthur C | Preidis, Geoffrey A | Elkins, Christopher A | Hill, Colin | Lewis, Zachery T | Shane, Andrea L | Zmora, Niv | Petrova, Mariya I | Collado, María Carmen | Morelli, Lorenzo | Montoya, Gina A | Szajewska, Hania | Tancredi, Daniel J | Sanders, Mary Ellen | 0000-0002-8808-6907 | 0000-0001-5995-6929 | 0000-0003-1745-4343 | 0000-0001-8348-0633 | 0000-0002-2206-6452 | 0000-0002-6029-9812 | 0000-0002-8527-1445 | 0000-0002-7725-2869 | 0000-0003-0606-7188 | 0000-0001-7928-316X | 0000-0002-0840-5294 | 0000-0002-6204-4864 | 0000-0003-0475-2712 | 0000-0003-2848-1339 | 0000-0002-4596-2874 | 0000-0002-3884-7907 | 0000-0001-6321-3423 | Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
Probiotics are used for both generally healthy consumers and in clinical settings. However, theoretical and proven adverse events from probiotic consumption exist. New probiotic strains and products, as well as expanding use of probiotics into vulnerable populations, warrants concise, and actionable recommendations on how to work toward their safe and effective use. The International Scientific Association for Probiotics and Prebiotics convened a meeting to discuss and produce evidence-based recommendations on potential acute and long-term risks, risks to vulnerable populations, the importance for probiotic product quality to match the needs of vulnerable populations, and the need for adverse event reporting related to probiotic use. The importance of whole genome sequencing, which enables determination of virulence, toxin, and antibiotic resistance genes, as well as clear assignment of species and strain identity, is emphasized. We present recommendations to guide the scientific and medical community on judging probiotic safety.
Show more [+] Less [-]ISAPP provided travel funding for non-industry-affiliated members of this expert panel. ISAPP is funded by equal contributions from member companies involved in the development, assessment, or marketing of probiotic or prebiotic products. Although ISAPP receives funds to support its activities from commercial sources, its activities and positions are set by an all-academic, volunteer board of scientists. Industry members have no control over the positions of the organization.
Show more [+] Less [-]Peer reviewed
Show more [+] Less [-]AGROVOC Keywords
Bibliographic information
This bibliographic record has been provided by Instituto de Agroquímica y Tecnología de Alimentos