Synthesis and Utility of 2,2-Dimethyl-2 H-pyrans: Dienes for Sequential Diels-Alder/Retro-Diels-Alder Reactions
2018
Tejedor, David | Díaz-Díaz, Abián | Diana-Rivero, Raquel | Delgado-Hernández, Samuel | García-Tellado, Fernando | Ministerio de Economía y Competitividad (España) | European Commission | Agencia Canaria de Investigación, Innovación y Sociedad de la Información | Universidad de La Laguna | Cajasiete | García-Tellado, Fernando [0000-0001-6470-6289]
The practical use of 2,2-dimethyl-2H-pyrans as electron-rich dienes in sequential Diels−Alder/retro-Diels−Alder (DA/rDA) domino processes to generate aromatic platforms has been demonstrated. Different polysubstituted alkyl 2-naphthoates have been synthesized by the DA/rDA reaction of benzynes and 2,2-dimethyl-2H-pyrans. The use of other activated alkynes allows the access of substituted alkyl benzoate derivatives.
Show more [+] Less [-]The authors thank the Spanish Ministry of Economy and Competitiveness (MINECO), the European Regional Development Funds (ERDF) (CTQ2015-63894-P), and the Canarian Agency for Research, Innovation and the Information Society (ACIISI) (ProID2017010019 ACIISI/FEDER, EU) for financial support. S.D.H. thanks La Laguna University and Cajasiete for a predoctoral contract.
Show more [+] Less [-]Peer reviewed
Show more [+] Less [-]Bibliographic information
This bibliographic record has been provided by Instituto de Productos Naturales y Agrobiología