Genotoxicity of the insecticide rotenone in cultured human lymphocytes
1998
Guadaño-Ferraz, Ana | González-Coloma, Azucena | Peña de Torres, Eduardo de la
7 páginas y 6 tablas estadísticas
Show more [+] Less [-]We have investigated the genotoxic activity of rotenone on three genetic endpoints, sister-chromatid exchanges (SCE), chromosome aberrations (CA)and micronuclei (MN) in human lymphocyte cultures in the presence and absence of a metabolic activation system (S9 mix). Our results indicate that rotenone increases the frequency of binucleated micronucle- ated (BNMN)cells and causes a delay in the cell cycle but does not increase the frequency of CA and SCE at the concentrations used. The presence of S9 mix reduces the genotoxic activity of rotenone.
Show more [+] Less [-]This work was supported by a grant from the DGICYT-Spain (PB 94/0020/B).
Show more [+] Less [-]Peer reviewed
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