Efecto de la sedación con dexmedetomidina sobre la presión intraocular y el espesor central de la cornea en perros | Effects of the dexmedetomidine sedation on intraocular pressure and on the central cornea thickness in the dog

Objetivo: Determinar el efecto de la sedación con dexmedetomidina sobre la presión intraocular (PIO) y el espesor central de la córnea (ECC) en perros Material y métodos: Estudio realizado en 10 perros a los que se midió la PIO y ECC basales y tras administración tópica de tropicamida 1%. Seguidamente sedamos con dexmedetomidina 5μg/kg IV y valoramos PIO y ECC a los 5,10, 15 y 20 minutos post-sedación. Los valores medios se compararon mediante la prueba t de Student para muestras pareadas. Resultados: Los valores medios basales de PIO fueron media ± D.E. 10,95 ± 1,70 mmHg; y 571 ± 21,42 μm para el ECC. No existe asociación significativa entre PIO y ECC (r= -0,2399). La midriasis no varió significativamente los valores de PIO (P= 0,3665) pero sí el ECC (P=5,6109x10-6). La sedación con dexmedetomidina no varía significativamente los valores de PIO ni ECC (P>0,05). Conclusiones: La midriasis provocada por tropicamida 1% disminuye significativamente el ECC pero no la PIO. La sedación con dexmedetomidina 5 mg/kg IV no varía significativamente los valores basales de PIO ni del ECC.

Objective: to determine the effects of the dexmedetomidine sedation on intraocular pressure (IOP) and on the central corneal thickness (CCT). Material and methods: this study has been performed over 10 dogs treated in the Veterinary Clinical Hospital of Córdoba University. The IOP and the CCT were measured before and after administration of one drop of 1% tropicamide. Thereafter, they were sedated with dexmedetomidine 5 μg/kg IV, and IOP and CCT were evaluated at 5, 10, 15 and 20 minutes after sedation. A t-Student test was performed with paired samples of mean values in order to compare both groups. Results: Basal values of IOP were 10.95 ± 1.70 mmHg, whereas CCT mean values were 571 ± 21.42μm. There were no statistically significant association between IOP and CCT (Pearson correlation r= -0.2399). Mydriasis did not significantly change the values of IOP (P= 0.3665), but did the CCT ones (P= 5.6109x10-6). No statistically significant differences were found between the IOP nor the CCT values before and after sedation with dexmedetomidine (P>0.05). Conclusions: tropicamide-induced mydriasis does not affect IOP value, but it causes a significant decrease of the CCT value. Sedation with 5 g/kg IV dexmedetomidine has not statistically significant effect on IOP or CCT.