Borna disease virus in patients with psychiatric disorders or fibromyalgia - demonstration of antibodies is highly dependent on the detection method
1999
Batra | Schrott, K. | Stitz, Lothar
In the past a possible association between Borna disease vims (BDV)-infection and psychiatric disorders in man was proposed. We investigated sera from patients with schizophrenia, major depression and fibromyalgia for the presence of BDV-specific antibodies and examined the sensitivity of different detection methods for virus specific antibodies. Performing Western blot analysis, immunofluorescence assay and virus neutralisation assay we received inconsistent results. We found a high prevalence (10%) of BDV-specific antibodies in the sera of schizophrenic patients using Western blot, but could not confirme these data by immunofluorescence or virus neutralisation assay. These inconsistent results indicate the need for a critical review of all reported results of significantly enhanced seroprevalence of BDV antibodies in neuropsychiatric patients.
Show more [+] Less [-]Bibliographic information
Publisher Springer
This bibliographic record has been provided by Friedrich-Loeffler-Institut
