Fish as a model organism to study skeletal development and associated pathologies
2008
Gavaia, Paulo J. | Cancela, Leonor
The physiological and molecular processes that regulate early cell differentiation and maturation, matrix deposition, morphogenesis and maintenance are under strict control during ontogenic skeletal development of vertebrates. A large research effort on the sequencing and genetic characterization of model fish such as zebrafish, medaka, fugu or seabream in the last two decades has provided numerous studies at various levels on the regulation of skeletal formation and demonstrated that similar developmental events occur both in mammalian and non mammalian systems.
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