Comparación del perfil lipídico y del perfil tiroideo en caninos adultos obesos vs caninos adultos normales | Comparison of lipid profile and thyroid profile in obese adult canine vs normal adult canine

Se estudiaron, en caninos adultos obesos vs. caninos adultos normales, el metabolismo energético y el tiroideo. Se obtuvo suero en ayunas de 80 caninos adultos (40 caninos obesos mayores de un año y 40 caninos normales mayores de un año). Los niveles tirotropina (TSH) y tiroxina libre (T4L) se determinaron mediante inmunoensayo enzimático; los valores de colesterol total (CT), triacilglicéridos (TAG) y colesterol HDL (C-HDL) por métodos enzimáticoscolorimétricos; los niveles de colesterol LDL (C-LDL) mediante el método directo y los de colesterol VLDL (C-VLDL) con la fórmula de Friedewald (TAG/5). Los valores de promedio de TSH (μUI/ml), T4L (ng/dl), CT (mg/dl), TAG (mg/dl), C-HDL (mg/dl), CVLDL (mg/dl) y C-LDL (mg/dl) para los caninos obesos fueron: 1,04; 1,05; 242,44; 58,82; 162,9; 11,75; 71,68 respectivamente. Para los caninos adultos normales fueron: 1,27; 0,93; 201,49; 37,57; 134,94; 7,42; 49,34 respectivamente. No se encontró diferencia significativa en los niveles de TSH y T4L en caninos adultos obesos vs. caninos adultos normales, (P-valor: 0,51; 0,26 respectivamente). Para todo el perfil lipídico sí se observó diferencia significativa. No se observó diferencia significativa al comparar entre sexos, con una confiabilidad del 95%. En conclusión, el perfil lipídico se encuentra francamente alterado en los caninos obesos. Con relación al perfil tiroideo no se encuentran diferencias significativas, a pesar de que algunos autores mencionan que el tejido graso incide incrementado los valores en este perfil.

The energy and thyroid metabolism were studied in obese adult canine vs. normal adult canine. Fasting serum from 80 adult canines was obtained (40 obese canines older than one year and 40 normal canines older than one year). The levels of thyrotropin (TSH) and free thyroxine (T4L) were determined by enzyme immunoassay. The total cholesterol (TC), triglycerides (TAG) and HDL cholesterol (HDL-C) values were determined by enzymatic-colorimetric methods. The levels of LDL cholesterol (LDL-C) were obtained by the direct method and those of VLDL cholesterol (VLDL-C) were obtained with the Friedewald formula (TAG/5). The mean values of TSH (μUI/ml), T4L (ng/dl), CT (mg/dl), TAG (mg/dl), HDL-C and LDL-C (mg/dl) for obese adult canines were: 1.04; 1.05; 242.44; 58.82; 162.9; 11.75; 71.68, respectively. For the normal adult canines, the mean values were: 1.27; 0.93; 201.49; 37.57; 134.94; 7.42; 49.34, respectively. No significant difference was found in the levels of TSH and T4L in adult obese canines vs. normal adult canines (P-value: 0.51; 0.26, respectively). A significant difference was observed for the lipid profile. No significant difference was observed when comparing male/female canines with 95% reliability. In conclusion, the lipid profile is clearly altered in obese canines. Regarding the thyroid profile, no significant differences were found, although some author mention that fatty tissue affects this profile.