Probiotics as a potential tool for gynecological cancers prevention and therapy suport
2024
Kuźmycz, Olga | Wierzbińska, Wiktoria | Kuźmycz, Olga - University of Lodz, Faculty of Biology, Department of Molecular Microbiology, Poland | Wierzbińska, Wiktoria - University of Lodz, Faculty of Biology, Department of Molecular Microbiology, Poland; BioMedChem Doctoral School of the University of Lodz and Lodz Institutes of the Polish Academy of Sciences, Poland | Kuźmycz, Olga - olga.kuzmycz@biol.uni.lodz.pl | Wierzbińska, Wiktoria - wiktoria.wierzbinska@edu.uni.lodz.pl
The human body is host to a variety of microbial species that are essential for maintaining general health. About nine percent of these microbial species inhabit the urogenital tract. It is therefore important to establish a symbiotic relationship between the host’s immune system and the microbiota in this region. Disruptions of this symbiosis can contribute to the development of pelvic inflammatory disease (PID), bacterial vaginosis (BV), vaginal candidiasis and/or even gynaecological cancers by promoting the proliferation of infectious agents. The chemotherapeutic agents currently used in cancer treatment are associated with undesirable side effects. Therefore, there is an urgent need for antitumor agents that have minimal toxicity compared to conventional treatments. Furthermore, the use of drugs to prevent or alleviate the side effects of cervical cancer treatment could significantly improve the quality of life of patients undergoing such therapy. In this review, we focus our attention on the potential efficacy of probiotics in both the prevention and therapeutic intervention of neoplasms affecting the genital tract.
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