Evaluación del efecto tóxico muscular y renal de la atorvastatina en conejos hipercolesterolemicos

El estudio se realizó en las instalaciones de la Universidad de La Salle con 20 conejos del mismo sexo, edad y raza, a los cuales se les administró una dieta rica en colesterol antes de iniciar el estudio. Los conejos con niveles de colesterol mayores a 300 mg/dl ingresaron al estudio. El total de animales se dividió en 2 grupos homogéneos elegidos al azar. A los animales del grupo no tratado se les mantuvo la dieta hipercolesterolémica y se les administró placebo durante 16 semanas. A los animales del grupo tratado se les administró la dieta hipercolesterolémica de igual forma que al grupo no tratado y se les administró Atorvastatina a dosis de 1.25 mg/kg durante las mismas 16 semanas. Las técnicas utilizadas para la obtención de resultados fueron: medición de las concentraciones séricas de BUN, creatinina, CPK y mioglobina sérica; parcial de orina, mediciones semanales de peso, análisis cualitativo del consumo de droga/placebo, alimento, estado de salud y estudio histopatológico de músculo y riñón de cada uno de los animales del estudio.

The present study was realized at the University La Salle, there was used 20 rabbits, same sex, age and race. To this animals it was administrated a rich cholesterol diet before initiated the study. The animals with cholesterol levels higher than 300 mg/dl got into the study. The animals were divided into two groups. One group was de control group, these animals received rich cholesterol diet and placebo treatment and the other group, experimental group received rich cholesterol diet and atorvastatin (1.25 mg/kg). The study duration was 16 weeks. In order to obtain results, there were employed then following techniques: BUN, CPK, creatinine and myoglobin blood measurement. Urine analysis was made at the end of study. A weekly control on feeding, weight, health and atorvastatin consumption was made. Finally, there were obtained muscle and kidney samples for pathological analysis. Because of the studies absence about this kind of experimental work, we had so many difficulties in other to get a specific diagnostic. However, the findings at the end of study demonstrated that there is no presence of any kind of lessons on muscle or kidney tissue on those hypercholesterolemic rabbits during the study duration.

Medicina Veterinaria