Criteria for the assessment of the value of post-infective antirabies treatment [viral diseases]
1983
Ercegovac, D. (Faculty of Veterinary Medicine, Beograd (Yugoslavia). Institute of Veterinary Preventive Medicine)
This paper discusses application of post-infection anti-rabies treatment (vaccination) and presents following conclusions: -Lethal results, despite sufficient titer of antibodies confirm that an irreversible link between rabies virus and central nervous system is established before immunity. -The reason for lethal results after post-infection treatment of animals and people is not in the vaccine, because it stimulates sufficient titre of antibodies. The reason lies neither in virulence, nor in the quantity of virus, but only in that the virus reaches central nervous system before antibodies are formed. This confirms existence of axonal circulation, because only in this way the virus can reach central nervous system so early. -Since the actively-formed antibodies cannot protect, animals which are vaccinated after being infected can survive only thanks to natural resistance. Post-infection anti-rabies vaccination cannot be useful at all. On the contrary, it destimulates other measures which are successfully applied in preventing rabies.
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