Studies on development of Escherichia coli subunit vaccine against calf diarrhea, 2; immunogenicity and protective efficacy of Escherichia coli K99 and F41 pilus vaccines in experimental animals
1986
Kim, J.M. | Yoon, Y.D. | Park, J.M. (Rural Development Administration, Anyang (Korea R.). Veterinary Research Inst.) | Kim, B.H. (Kyongbuk National Univ., Taegu (Korea R.). Dept. of Veterinary Medicine)
The oil emulsion and alhydrogel pilli vaccines were prepared from a strain (O9: K35, K99, F41) of enterotoxigenic Escherichia coli isolated from calves with diarrhea and their immunogenicity was tested in guinea-pigs, pregnant goats and cows. Serum antibody responses to K99 and F41 antigens in guinea-pigs given experimental oil and gel vaccines peaked at 4 and 6 weeks after vaccinations. At that time, the mean hemagglutination inhibition titers to K99 and F41 antigens in guinea pigs given oil vaccine were 1:25 and 1:1,218 and those given gel vaccine were 1:54 and 1:724 respectively
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