Physicochemical study on the synthesis of progesterone immunogen
1986
Park, J.H. (Korea Advanced Inst. of Science and Technology, Seoul (Korea R.)) | Kwun, J.K. (Seoul National Univ., Seoul (Korea R.). Dept. of Veterinary Medicine)
Progesterone immunogen has been synthesized and its melting point, Rf-value, UV and IR spectrum have been measured to develop the essential step in antisera production against low molecular weight substance. Mixed anhydrid reaction was used to conjugate 11 alpha-hydroxy-progesterone with succinic anhydride. Melting point of one intermediate compound was 156 deg C, and Rf-value was 0.41 in benzene: acetone: methanol (5:5:2).
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