Effect of xylazine hydrochloride, yohimbine hydrochloride, and 4-aminopyridine on gizzard motility in chicken
1988
Kim, K.S. | Park, J.H. (Kyongbuk National Univ., Taegu (Korea R.). Coll. of Veterinary Medicine)
Xylazine hydrochloride is a widely used analgesic, sedative and muscle relaxant in veterinary clinic. Yohimbine hydrochloride and 4-aminopyridine are known as antagonists of xylazine hydrochloride. This paper investigated whether or not there exists an antagonism of yohimbine hydrochloride and 4-aminopyridine to xylazine hydrochloride. After xylazine hydrochloride administration, the gizzard motility in chicken was instantly inhibited in relaxation state, and this state was prolonged as the dose was increased. After yohimbine hydrochloride administration, the gizzard motility in chicken showed increase of contractile frequency. After 4-aminopyridine administration, the gizzard motility in chicken was gradually recovered next to decrease of contractile amplitude and frequency. After the combination of yohimbine hydrochloride and 4-aminopyridine administration, the gizzard motility in chicken showed increase of amplitude and radical increase of frequency. After xylazine hydrochloride administration, the relaxation time was shortened by yohimbine hydrochloride, 4-aminopyridine and the combination of yohimbine hydrochloride and 4-aminopyridine. In conclusion, the gizzard motility in chicken was inhibited by xylazine hydrochloride, and this effect was antagonized by combination of yohimbine hydrochloride and 4-aminopyridine
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