Effects of Malathion on the development of the chick embryo cerebrum
1988
Kim, W.J. | Deung, Y.K. (Yonsei Univ., Wonju (Korea R.). Wonju College of Medicine) | Choe, R.S. (Yonsei Univ., Seoul (Korea R.). Dept. of Biology)
Chick embryos which have received a single injection of the organophosphate compound, malathion (0.1mg, 0.5mg, 1.0mg or 2.0mg in 0.05ml of corn oil) via the yolk sac at certain times (2 dys, 4 days or 6 days after incubation) have been investigated. After 9 days of incubation, chick embryos were harvested to investigate the effects of malathion on the development of cerebrum morphologically and biochemically. The effects of simultaneous injection of malathion and nicotinamide were also compared. On ultrasturctural examination, neurons in cerebral cortex showed to be inhibited in their differentiation by malathion; nuclear irregularity, swelling of endoplasmic reticulum, and cytoplasmic vacuoles were observed. On cytochemical study of acetylcholinesterase(AChE) by electron microscope, the positive reaction products of this enzyme were localized at the membrane of nucleus and endoplasmic reticulum of neurons. Inhibition of AChE activity was severe in groups treated with relatively low doses, which was consistent with the results of spectrophotometric analysis. The activity of lactate dehydrogenase(LDH) of cerebrum in groups treated with malathion was higher than that of the control group
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