Antitumor activity of seaweeds toward sarcoma-180
1989
Ryu, B.H. | Kim, D.S. | Cho, K.J. (Kyungsung Univ., Pusan (Korea R.). Dept. of Food Science and Technology) | Sin, D.B. (Pusan National Univ., Pusan (Korea R.). Dept. of Nutrition)
Protein-polysaccharides (PP) extracted from four species of gulfweed, fusiforme, sea-mustard and sea-tangle were examined for antitumor activity toward sarcoma-180 implanted in mice, ICR. Polysaccharides in protein-polysaccharides extracted from gulfweed, fusiforme, sea-mustard and sea-tangle were 61.48, 55.61, 34.06 and 30.28 %, respectively. Monosaccharides of four seaweeds consisted of glucose, galactose, mannose, fructose and xylose, and major amino acids consisted of glutamic acid, aspartic acid, cystein, valine and glycine. Antitumor activity of the protein-polysaccharides extracted from sea-mustard showed the highest inhibition ratio of 69.76 % when PP was injected to the mice at the dose of 100 mg/Kg/day. PP of sea-tangle showed the maximum survival ratio of 25.22 % when injected at the dose of 100 mg/Kg/day
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