Immunocytochemical localization of raf protein kinase in cerebrum of Geoclemys reevesii (gray)
1990
Choi, W.C. | Moon, H.K. (Pusan National Univ., Pusan (Korea Republic). Coll. of Natural Sciences)
Raf protein kinases and protein kinase C belong to serine/ threonine-specific proteins in the cytoplasm, and are similar to each other in functional structure and the aspect of the distribution of cell. The distribution of raf protein kinase in the cerebrum of Geoclemys reevesii was studied by using the antibodies against a-raf and c-raf protein kinase which induce the expression of raf family oncogenes. In general, raf protein kinases were distributed in such restricted regions as the general pallium, hippocampal formation, primordium hippocampi, nucleus of lateral olfactory tract, basal amygdaloid nucleus, and bed of stria teminalis. Immunological labeling of c-raf protein kinase was more widespread than that of a-raf. However, the intensity of the labeling of c-raf was lower than that of a-raf. The spherical cells of basal amygdaloid nucleus is a ring-like form, because only the cytoplasm was immunolabeled. Especially, c-raf protein kinase occurred in the cells which contained protein kinase C abundantly such as pyramidal cells and Purkinje cells. This suggests that a-and c-raf protein kinases may synergistically induce carcinoma with myc gene which is activated by protein kinase C
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