Effect of diet enrichment with fatty acids from the n-3 and n-6 group on lipid content in serum and organs on the development of atherosclerosis in rats
1990
Ziemlanski, S. | Panczenko-Krasowska, B. (National Food and Nutrition Institute, Warszawa (Poland). Dept. of Nutrition Physiology)
In a long-term study the effects of on n-3 and n-6 polyunsaturated fatty acids on certain lipid metabolism parameters were compared. Male Wistar rats were divided into three experimental groups and were given diets with added studied fats. The diets contained 15 percent of energy from fats (7.5 g/100 g of diet) such as fish oil, sunflower oil and mixture of butter and lard. At time intervals of 4 weeks, 12 weeks and 12 months the rats were decapitated and lipids were determined in their serum and tissues. In the aorta the extent of fat deposits was measured planimetrically. Fish oil was found to reduce most evidently the level of total cholesterol in serum and tissues. Sunflower oil in a lower degree decreased the accumulation of cholesterol in rat organism but increased the concentration of HDL-cholesterol. The atherogenic index in this group was lowest, and the extent of atheromatous lesions was least pronounced. The atherogenic effect of animal was confirmed
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