Experimental infection of rabbits with a single metacercaria or a newly excysted juvenile fluke of Japanese Fasciola sp. and American Fasciola hepatica
1990
Kawano, J. (Kobe Univ. (Japan). Faculty of Agriculture) | Shimizu, A. | Umeda, S. | Koga, M. | Kimura, S.
Rabbits were experimentally infected either perorally with a single metacercaria or intraperitoneally with a newly excysted juvenile fluke of Japanese Fasciola sp. and American Fasciola hepatica. No clinical signs were noted. Fluke eggs were first detected in feces at the 63rd and 53rd post infection days for F. sp. and F. hepatica, respectively. Precipitating antibodies were first detected in sera at the 4th post infection week for both of the Fasciola species. Gross lesions showing adhesions, haemorrhages, nodules, scars, hyperplasia of connective tissue and thickening of the bile duct were all moderate. Histopathologically, tract lesions and haemorrhages were noted. In hematological examinations, no remarkable changes were observed in erythrocyte counts, leukocyte counts and hemoglobin content. Eosinophil percent increased in 6-8 weeks after infection. In biochemical examinations of sera, no remarkable changes were noted in concentrations of total protein, albumin and globulin, and the GOT activity. The GPT activity and total cholesterol concentration increased at the 10th and 9th post infection weeks, respectively, in the rabbits infected with F. sp. Hatching rates of fluke eggs that were collected from the gallbladder of the infected rabbits were 5-46 % for F. sp. and 7-71 % for F. hepatica. While, hatching rates of eggs that were collected from those infected with a multiple dose of Fasciola were 18-57 % for F. sp. and 67-81 % for F. hepatica. Body size and development of the inner organs of the flukes recovered from the rabbits that were infected with a single dose were the same as those recovered in the infections of multiple dose of the Fasciola species
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