Effect of local hyperthermia on chickens transplanted with MC29-induced liver tumor
1992
Ishizu, A. (Kagoshima Univ. (Japan). Faculty of Agriculture) | Nakagawa, M. | Makiuchi, H. | Yasuda, N. | Shimizu, T.
1. A transplantable liver tumor induced by MC29 virus, whose specific utilization of glutamine in growth of the tumor had been well demonstrated, was implanted into the subcutis of the day-old chickens, and after 7-8 days when the tumor reached a soybean size, the local hyperthermia with microwave and/or chemotherapy with 6-diazo-5-oxo-1-norleucine (DON) were given for 7 days successively. A heating schedule of 3 min/day was devised and adopted. 2. On the 7th day of the experiment, the tumor growth ratio expressed by mean +- standard deviation was 14.3 +- 1.81 in the tumor control group; 6.93 +- 0.95 in DON group; 3.24 +- 2.25 in the local hyperthermia group; and 0.61 +- 0.57 in DON + hyperthermia group, respectively. 3. The body weight gain ratio in the local hyperthermia group was evidently higher than that in the tumor control group. The body weight gain was suppressed most remarkably by DON. 4. In the present transplantable tumor system, local hyperthermia was more effective in tumor suppression, and less hazardous to the host than our former whole body hyperthermia. 5. In the histopathological study of the present local hyperthermia, slight but obvious degenerative changes were shown by the tumor cells beneath the surface skin after the first 3 min of heating schedule. After one day necroses became obvious in almost all the tumor cells, with the exception of those located at the bottom or at the lower periphery of the tumor mass. When the tumor regressed, resorption and fibrosis became evident, being surrounded with lymphoid cell foci
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