Studies on the "pilus" vaccines: productivity and selection of vaccine strains
1994
Juhkam, A. | Laasik, E. (Estonian Research Institute of Animal Breeding and Veterinary Science, Tartu (Estonia)) | Heinaru, A. (Tartu University, Tartu (Estonia))
In newborn calves and piglets infectious diarrhea is caused by enteropathogenic E. coli as most frequent gastrointestinal disease in farms. Various types of biopreparates including vaccines from enteropathogenic Escherichia coli strains were used as immunoprophylactical preparates against diarrhea. E. coli strains have different plasmids which determine the production of "pilus" antigens (K88, K99, P87 etc.). Those antigens are proteins which appear as favourite attachment and colonization of the cells of enteropathogenic E. coli to the epithelium of the small intestine of newborns. The "pilus" antigens are not toxic themselves but small plasmids determine the synthesis of thermostabile (ST) or thermolabile (LT) toxins. The aim of the present work was to investigate productivity of the K99 "pilus" vaccine form strain E. coli B41 (O101 K99 H) and secondly to investigate expression of "pilus" protein on "pilus" antigen possessing enteropathogenic strains
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