Reinfusion of UV-irradiated blood in the treatment of staphylococcal infection
1997
Rosina, J. | Vymola, F. (Karlova Univ., Prague (Czech Republic). 3. Lekarska Fakulta) | Starec, M. | Celko, A.M.
Reinfusion of ultraviolet (UV)-irradiated blood with maximum absorption of 254 nm revealed the therapeutic effect on the course of staphylococcal infection. As the wave-length region about 254 nm is dangerous for DNA, we decided to study the possible therapeutic effect of UV-irradiated blood method in model staphylococcal infection using a wave-length of maximum of 365 nm. Our results in rabbits showed the favourable effect of reinfusion of UV-irradiated blood also in this wave-length maximum. All control rabbits inoculated with the virulent strain of S. aureus H 476 (2 x 10**5 per 1 kg of body weight) died within 40 hours after infection. On the other hand, rabbits inoculated with the same dose of S. aureus but treated with UV-irradiated blood did not die within 28 days of observation and no serious pathological changes were found in sections.
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