Studies on growth, drug accumulation and residue in the muscle liver kidney and blood of the catfish Clarias batrachus Linneaus after administered with various doses of chlortetracyclin (Aureomycin)
1992
Prasoet Sitasit | Somphon Srirot | Prem Chunthanom (Department of Fisheries, Bangkok (Thailand). National Inland Fisheries Inst.)
Three groups of walking catfish (Clarias batrachus Linneaus) were separated, 1st and 2nd groups were fed by pelleted supplementary diet mixed with antibiotic, chlortetracyclin, at the rates of 0, 100, 200 and 100, 200 mg per 1 kg of diet for 21 weeks and 7 days, respectively. For the 3rd group, the antibiotic was fed one time by oral taking at the levels 50 and 100 mg per kilogram of body weight. The growth rate and survival rate of the fish in 1st group were not statistically different through the experimented period. Drug level in blood which was higher than 0.125 micro g/ml was found only 24 hours period, for the 3rd group. After 4 hours of oral taking, the accumulation of Chlortetracyclin in liver and serum were 1.5 micro g/gm, 1.1 micro g/ml and 3.8 micro g/gm, 2.8 micro g/ml for drug levels 50 mg and 100 mg of body weight, respectively. No residues of Chlortetracyclin could be detected in various organs muscle and blood of 1st and 2nd group, after 3 days of feeding period and after 4 days of oral taking in 3rd group.
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