Effect of aujeszky's disease virus infection on the immune response against swine fever
1990
Satra, J. | Kongthon, S. (Dept. of Livestock Development, Bangkok (Thailand). Veterinary Biologies Div.) | Sutherat, J.
Purpose of this study is to investigate the effect of Aujeszky's disease virus (ADV) on the immune response against swine fever. Groups of ADV-infected and uninfected pigs, modified live ADV-vaccinated pigs challenged with virulent ADV and killed ADV-vaccinated pigs challenged with virulent ADV were separated for studying. Each group was vaccinated with swine fever vaccine at one month after infection or challenge, except two pigs in each group were left unvaccinated and served as controls. All pigs were challenged with virulent swine fever virus at 14 days after vaccination and observed for 21 days. All dead pigs were examined for pathological lesions. All surviving pigs were killed on day 21 after challenge and examined for pathological lesions. The results indicated that the infection of ADV or vaccination with modified lived ADV or vaccination with killed ADV after challenged with virulent ADV had no effect on the immune response against swine fever, all vaccinated pigs were protected against the challenge of swine fever virus, while unvaccinated control pigs died after challenge.
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