Identification of bovine somatotropine-treated cows | Identification des vaches laitieres traitees a la somatotropine bovine
1997
Scippo, M.L. | Degand, G. | Duyckaerts, A. | Maghuin-Rogister, G. (Liege Univ. (Belgium). Faculte de Medecine Veterinaire. Dept. des Sciences des Denrees Alimentaires d'Origine Animale)
Bovine somatotropin (BST also called bovine growth hormone) is an efficient enhancer of milk production. The safety of BST treatment is now well demonstrated both for animals and for human consumers of foodstuffs from animal origin. Up to now, the administration of BST in the recombinant form (rec-BST) has been authorised in several countries including India, South Africa, USA, Czechia, Slovakia, the Community of Independent Republics (CSI), but is still under examination in the European Union countries. A control strategy is thus required for the use of BST, not only because BST is not authorised in Europe, but also because illegal treatments could interfere in the genetic selection of genitor animals. It is, however, impossible to discriminate quantitatively between untreated and BST-treated cows by measuring plasma BST concentrations, which are in the same range in treated and untreated animals. BST used for treatments are produced using recombinant DNA technology. They are essentially produced by four companies: American Cyanamid, Eli Lilly-Elanco, Monsanto and Upjohn. They are very close structurally to the pituitary BST, except for some aminoacids at the N-terminal region of the protein. Three different methods to detect treated cows are proposed. The first technique is a method to detect erogenous BST in the plasma of treated cows using a mass spectrometry technique (electrospray-MS). Secondly, anti-BST antibodies in BST-treated animals could be detected. Thirdly, the IGF-BP2 concentration could be measured in cow plasma since it is known to be negatively regulated by growth hormone.
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