Anti-inflammatory, antimutagenicity, and antitumor-promoting activities of mahogany seeds, Swietenia macrophylla (Meliaceae)
1996
Guevara, A.P. | Apilado, A. | Sakurai, H. | Kozuka, M. | Takuda, H. (Philippines Univ. Diliman, Diliman, Quezon City (Philippines))
The crude ethanol extract of mahogany (Swietenia macrophylla King) seeds was tested for anti-inflammatory, antimutagenic, and antitumor-promoting activities. Solvent fractions of the ethanol extract, namely hexane, CCl4 and methanol fractions were also tested for their anti-inflammatory and antitumor-promoting activities. At a dosage of 1 mg per gram body weight of the test mice, the ethanol extract reduced carrageenan-induced inflammation by 79 percent. Less activities were observed for the solvent fractions, with the highest inhibition given only at 60 percent for the methanol fraction and a low of 23 percent inhibition for the hexane fraction. These observations indicate anti-inflammatory activity. Mutagenicity/antimutagenicity of the ethanol extract was studied using the Micronucleus test. The results indicate antimutagenicity of the crude extract. At a dosage of 0.02 mg per gram body weight, the extract reduced the number of micronucleated polychromatic erythrocytes induced by mitomycin C, a known mutagen, by almost 50 percent. The antitumor promoting activity of the crude extract and the solvent fractions were studied using the Epstein-Barr virus early-antigen (EBV-EA) activation, with 12-0-tetradecanoylphorbol-13-acetate (TPA) as the tumor promoter. The results indicate significant inhibitory effects on EBV-EA activation indicating the antitumor-promoting activity
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