A study of copper genotoxicity in the micronucleus test on mice
1997
Rusov, C. | Zivkovic, R. | Jojic-Malicevic, Lj. (Scientific Institute for Veterinary Medicine of Serbia, Belgrade (Yugoslavia). Department of Hematology)
Genotoxicological characterization of cupric acetate in the micronucleus test on BALB/c mice showed that small dose levels (0.5 and 5.0 mg/kg of body weight) and especially higher dose levels (10.0 and 25.0 mg/kg of b.w.) induce higher micronuclei counts (9.21 +- 1.30, 11.0 +- 2.64, 15.6 +- 2.07 and 20.3 +- 2.58) in polychromatic erythrocytes of the bone marrow. The count of induced micronuclei was statistically significant (P 0.001) compared to that of spontaneous micronuclei (2.2 +- 1.30) found in control mice inoculated with physiological saline solution, but also somewhat lower than in mice treated with cyclophosphamide (23.8 +- 1.79). Thus, the results of the investigation showed that cupric acetate in the investigated dose levels, inoculated intraperitoneally in to mice had a mutagenic effect.
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