Seaweed tablet: a natural source of iodine
1997
Briones, A.V. | Ambal, W.O. | Monroyo, E.C. | Bonifacio, T.S. | Sison, F.M. (Industrial Technology Development Inst., Bicutan, Taguig, Metro Manila (Philippines))
Species of seaweeds namely: Halymenia durvillaei, Laurencia flexilis and Sargassum gigantifolium were processed into dried form and formulated as tablet. Prior to tablet formulation, the seaweeds were assayed for iodine and trace elements. The seaweeds that exhibited significant values of iodine and trace elements were further analyzed for the presence of heavy metals followed by acute oral toxicity test (LD50). Among the seaweeds evaluated, H. durvillaei was found to contain high level of iodine (0.255 percent w/w) and magnesium (1.65 percent w/w) with sufficient amount of zinc (25.69 ppm) and phosphorus (11.68 ppm). Analysis of heavy metals showed minute amount of mercury (0.0055 ppm), cadmium (0.67 ppm) and lead (1.80 ppm). The median lethal dose (LD50) of H. durvillaei administered orally in Swiss male mice is 119.1489 plus or minus 4.9873 g/kg. Tablet formulation was based on the U.S. recommended daily allowance of 0.15 mg of iodine per adult and children. The final product was comparable to imported kelp pills (available in the local market) in terms of physical properties and iodine content
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