Pregnancy associated glycoproteins in rumninants: inactive members of the aspartic proteinase family
1999
Beckers, J.F. | Drion, P.V. | Garbayo, J.M. | Perenyi, Z. | Zarrouk, A. | Sulon, J. | Remy, B. | Szenci, O.
The Pregnancy Associated Glycoproteins (PAGs) presented in this paper are largely expressed in the ruminant placenta. These proteins are classified as probably inactive members of the aspartic family. Pepsinigen, renin, catheosin E & D and chymosine are typical members of this family, characterised by the presence of aspartic acids boarding the recognition sites. Secreted in the peripheral blood of the pregnant female from early pregnancy, these proteins can be used in serological tests for establishing different diagnoses. In the veterinary practice, these diagnoses are useful both pregnancy confirmation and follow-up of trophoblactic function.
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