Pathological evaluation of renal changes induced by myltiple nephropathogenic factors in SPF chickens
1999
Kang, K.I. | Hahn, T.W. | Han, J.H. (Kangwon National University, Chuncheon (Korea Republic). Department of Veterinary Medicine) | Mo, I.P. | Kwon, Y.K. | Kang, M.S. (National Veterinary Research and Quarantine, Anyang (Korea Republic).)
Renal failure is one of the main causes of economic impacts in the poultry industry and complex syndrome with different severity of clinical signs caused by multiple nephropathogenic factors such as infectious bronchitis viral infection and excess salt and calcium in diet. To evaluate the correlation between severity of renal failure and the causative nephropathogenic factors, one-day-old specific pathogen free chickens were treated with either single causative factor or multiple causative factors described as above. Each group was designed as control for non-treated control, IB for infectious bronchitis virus (IB virus) infection, IBHNa for IB virus infection with high diet salt, IBHCa for IB virus infection with high diet calcium, IBHNC for IB virus infection with high diet salt and calcium, HNa for high diet salt, HCa for high diet calcium and HNC for high diet salt and calcium. Chickens were inoculated with IB virus at 1-day-old and remained on their respective diets until 21 day of age. Plasma Na+, Cl-, BUN, creatinine, calcium and uric acid values were examined. The results obtained were as follows; IB virus and high dietary calcium combined treatment showed elevated plasma uric acid. BUN and creatinine values were not characteristic on chicken renal failure. But plasma uric acid values were increased according to renal lesion. Hypercalcemia and hyperuicemia did not induce urate deposition and mineralization in the kidney.
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