The effect of streptomycin and penicillin on trace metal ions level in biological system
2000
Rehmani, F.S. | Noor, H. (Balochistan Univ., Quetta (Pakistan). Inst. of Biotechnology) | Khawaja, E.
The potentiometric data of streptomycin and penicillin with trace metal ions show that Fe(III) and CU(II) ions form very stable complexes with these antibiotics at physiological pH therefore prolonged therapy causes anemia. Ca(II) and Mg(II) ions do not form stable complexes. Cr(lll) ions competes with Fe(III) binding sites. Co(II) and Ni(II) ions form complexes at neutral pH. The results indicate that these antibiotics lower the minerals level in the biological system. So it should be taken with minerals.
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