Physiological effects of zinc-lead interaction in mammals
2001
Al-Ayed, M.I. (Teachers Coll., Riyadh (Saudi Arabia)) | Abbasi, A.R.
The influence of dietary zinc (5 and 60 microgram/ml of drinking water) on the toxicity of lead (100 microgram/ml) was studied in Sprague-Dawley rats fed a purified diet for 150 days. The present results indicated that high dietary zinc reduced the lead levels in most tissues. The antagonistic phenomenon between lead and zinc was also proved by reduction of zinc levels in the plasma, liver and femur of the lead- exposed rats. Lead administration caused an elevation of urinary delta- aminolevulinic acid (delta-ALA) throughout the course of experiment. This increase, however, was greater in the animals receiving low zinc intake. Erythrocyte zinc protoporphyrin (ZPP) was not only affected by lead, but also by dietary zinc and by time of administration of the rats. As expected, linear regression analysis of the data showed that RBC-Pb correlated highly with the activity of delta-aminolevulinic acid dehydratase (ALA-D), ZPP and urine delta-ALA activity. Moreover, plasma zinc content was also correlated with RBC-Pb and ZPP.
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