Efficiency of C-reactive protein for differentiation between physiological and pathological conditions in dog
2000
Vojtic, I. | Weingerl, S. | Kebric, F. (Veterinary Hospital, Maribor (Slovenia))
We report the differences between CRP concentration and total leukocyte number in 138 dogs with acute reproductive (R) illness (pyometritis, endometritis; n = 28), miscellaneous (M) pathology (gastroenteritis, hapatitis, cystitis, viral diseases and intoxications; n = 100) and clinically healthy (H) dogs (n = 10). For quantitation of CRP the rabbit polyclonal antibodies against human CRP were used (turbidimetric immunoassay, TIA). The median values of CRP were 27.95 mg/l, 8.65 mg/l and 2.50 mg/l for groups R, M and H, respectively. Total leukocyte number in groups R, M and H were 16.55 ~ 109/L, 11.90 ~ 109/L oz. 8.60 ~ 109/L, respectively. The differences in CRP concentrations among groups were significant (Kruskal Wallis analysis of variance, P0,001), whereas significant difference detected was in leukocyte number between R and H group (Dunn`s post hoc test, P0,05). Using the dog non-specific TIA we were able to differentiate between deseased and healthy dogs. Reference limits assesed (mean +/- 1.96 sd) in this investigation were between 0,000 mg/l and 5.326 mg of CRP/L of serum. These limits were appropriate to early diagnostic use for inflammatory deseases in the dog.
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