Pharmacokinetics and urinary excretion of ciprofloxacin in crossbred cow calves
2000
Singh, K. | Srivastava, A.K. (Punjab Agricultural University, Ludhiana (India)).
The pharmacokinetics, urinary excretion and dosage regimen of ciprofloxacin after it's single intravenous administration of 5 mg.kg1 was investigated in crossbred cow claves. At 1 min the concentration of ciprofloxacin in plasma was 10.3 0.10 g.ml which rapidly declined to 3.07 0.02 g.ml at 10 min. The minimum therapeutic concentration (0.0gml) in plasma was maintained up to 6 hr. the elimination half life and volume of distribution were 3.75 0.06 hr and 6.80 0.15 l.kg respectively. The distribution half life and AUC were 0.21 0.003 hr and 3.98 0.05 g.ml hr respectively. The total body clearance (ClB) and tissue/plasma (T/P) ratio were 1.24 0.02 L.Kg hr and 8.01 0.22 respectively. Approximately 18% of the total administered dose of ciprofloxacin was recovered in urine within 24 hr after administration. A satisfactory intravenous dosage regimen of ciprofloxacin in cow calves would be 6 mg. kg1 followed by 5 mg kg1 repeated at 12 hr intervals
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