Toxicity of baythroid-TM: Hematological effects in growing chicks of Gallus domesticus
2000
Ali, S.S. | Ali, N.S. | Rashid, S. | Shakoori, A.R. (Punjab Univ., Lahore (Pakistan). Dept. of Zoology)
Baythroid (TM), a mixture of methamidophos and cytluthrin, was administered orally to chicks as two concentrations (strong and weak) for 40 hours and 9 days, respectively. In strong dose (10 mg/kg body wt.) experiment the blood samples were collected from control and treated groups at 5, 10, 20 and 40 hours following administration of a single dose of insecticide. In weak dose experiment (5 mg/kg body wt./day), the blood was collected at 3, 6 and 9 days of insecticide administration and used to study various hematological parameters such as hemoglobin (Hb), total erythrocytic count (TEC), total leukocytic count (TLC) and hematocrit (Hct) estimation. The above data were used to evaluate mean corpuscular volume (MCV), mean corpuscular Hb (MCH) and mean corpuscular Hb concentration (MCHC). Baythroid-TM treatment as strong dose produce significant increase in Hb (32%, 41%, 28%, and 30%) and MCH (22%, 32%, 25% and 27%) contents at 5, 10, 20 and 40 hours, respectively. Rise in case of Hct (29%) and TEC (9%) was also observed, which was significant only at 5 hours treatment. The TLC also showed an increase, which was 39%, 48%, 34% and 20% at 5, 10, 20 and 40 hours treatments, respectively. Weak dose of insecticide produced significant decrease in TEC (16%, 15% and 11%) and Hb content, which was 24%, 16% and 21% at 3, 6 and 9 day treatments, respectively. MCV and TLC showed an increase only at 3 and 9 days insecticide feeding durations, respectively. It is concluded that 10 mg dose level of Baythroid-TM, administered for short duration has somewhat stimulatory effect on hemopoietic tissue in chicks, which may be a protective response but weak dose administered for relatively long duration indicated suppression of blood components.
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