Possible role of iron in the pathogenesis of pulmonary emphysema in rabbits
2001
Vucevic, D. (Medical Faculty, Belgrade (Yugoslavia). Institute of Pathophysiology) | Pesic, C. | Djarmati, D. | Djordjevic-Denic, G.
Oxidative stress has been recognized to be responsible for pulmonary tissue damage. Having in mind the important role of iron as a catalyser of the production of some oxidants, we examined the content of this transition metal in pulmonary tissue of rabbits with experimental emphysema induced by a hypercholesterolemic diet. Pulmonary emphysema was pathohistologically confirmed. For this study three groups of ten rabbits each were used: C - a control group fed on the usual diet for this species, O - a control group fed on an oil - containing diet, and Ch - an experimental group fed on a hypercholesterolemic diet. After two-months treatment lung iron content was significantly (p0.05) decreased in group Ch and highly significantly (p0.01) decreased in group O compared to group C. In comparison with group O lung iron content was highly significantly (p0.01) increased in group Ch. Our findings indicate a possible role for iron in the pathogenesis of pulmonary emphysema.
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