The use of a new model for the investigation of sepsis
2002
Stojanovic, D. (Faculty of Veterinary Medicine, Belgrade (Yugoslavia)) | Malicevic, Z. | Asanin, R.
The purpose of the investigation was to induce the clinical form of sepsis in rats by inoculation of pure cultures of certain species of microorganisms into the ligated caecum. The experiments were performed on 104 Wistar strain male rats of 190-240 g body weight. Clinically apparent sepsis in two groups of rats was induced in the following way: the previously emptied, tied off and washed out caecum was inoculated with pure cultures of Escherichia coli or Staphylociccus aureus. In the third group, sepsis was produced by the caecum content of the tied off and punctured caecum (a mixed culture of microorganisms). A false surgical intervention was performed in the control group by opening the abdomen. Clinically manifest symptoms of sepsis induced were described in the paper.
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