Nitric oxide synthase inhibition prevents acute QA [quinolinic acid]-induced neurotoxicity
2002
Vasiljevic, I. | Jovanovic, M. | Ninkovic, M. | Malicevic, Z. (Military Medicine Academy, Belgrade (Yugoslavia). Institute for Medicinal Research)
In the present study we employed 7-NI, reportedly a selective inhibitor of neuronal nitric oxide synthase (NOS) and the non-specific potent NOS inhibitor I-NAME, to investigate the possible involvement of nitric oxide (NO) in quinolinic acid (QA) - induced striatal toxicity in the rat. QA was administered unilaterally into the striatum of adult Wistar rats in the single dose of 150 nmol/L. The second and third group were treated with 7-NI and QA and I-NAME and QA. The control group was treated with 0.9% saline solution likewise. Nitrite levels were decreased in the ipsi- and contralateral striatum, forebrain cortex and hippocampus in the group treated with NOS inhibitors (7-NI, I-NAME) and QA compared to QA-treated animals. As 7-NI selectively inhibits the neuronal form of NOS, this study suggests that NO produced from a neuronal and not an epithelial source may contribute to neuronal damage in this model.
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