Phenobarbital effects on brain and liver tissues enzyme activity in Balb/C mice
2002
Yazar, E. | Demir, O. | Elmas, M. | Bas, A.L. | Tras, B. (University of Selcuk, Konya (Turkey))
The purpose of the present study was to investigate the effect of phenobarbital on some brain and liver tissue enzyme activities in Balb/C mice. Thirty male mice were administered phenobarbital (80 mg/kg body mass). Brain and liver samples were taken at 6, 12 and 24 h after drug administration. The activities of alkaline phosphatase, aspartate aminotransferase, gamma glutamyl transferase, and amylase were measured by autoanalyzer. Phenobarbital did not affect gamma glutamyl transferase and amylase activities in the brain and liver, and alkaline phosphatase and aspartate aminotransferase activities in the liver. Significant (P0.05) increases of alkaline phosphatase and aspartate aminotransferase activities were observed in the brain. These results suggest that brain may contribute to increased activities of these enzymes in serum in Balb/C mice.
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