Effect of single sublethal dose of permethrin on the development of muscle in newly hatched chick (Gallus domesticus)
2003
Anwar, K. (University of Azad Jammu and Kashmir, Muzaffarabad (Pakistan). Dept. of Zoology)
Present study was aimed at investigating the toxic effects of a single sublethal dose of various concentrations of permethrin insecticide (50, 100 and 200 ppm) on the muscle of newly hatched chicks following administration in to the eggs at day þ0þ of incubation. Muscles were analyzed for a few enzyme activities such as amylase, alkaline phosphatase, acid phosphatase, glutamate oxaloacetate transaminase, glutamate pyruvate transaminase and lactate dehydrogenase and some of the biochemical components like, glucose, glycogen, total proteins, soluble proteins, free amino acids, total lipids, cholesterol, urea, uric acid, DNA and RNA contents. The activities of amylase (100 and 200 ppm), AkP (200 ppm) and ALT (50,100 and 200 ppm) were decreased whereas the activity of LDH activity elevated (200 ppm). In contrast, the activities of AcP and AST remained unaltered. Among biochemical components glucose, soluble protein and urea were decreased, whereas glycogen, total proteins, total lipids, cholesterol and uric acid were increased. Total free amino acids, DNA and RNA contents remained unaltered. These biochemical changes indicate the muscle dysfunction in terms of its low motor activity.
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