Novel linkage mapping approach using DNA pooling in human and animal genetics. Pt. 2. Detection of quantitative traits loci in dairy cattle
2002
Pareek, Ch.S. | Pareek, R.S. | Walawski, K. (University of Warmia and Mazury, Olsztyn (Poland). Dept. of Animal Genetics)
The paper outlines the currently emerged novel strategies of linkage mapping to identify QTL based on selective DNA pooling with more emphasis on its theoretical pre-requisite to detect linked QTLs, applications, a general theory for experimental half-sib designs, the power of statistics and its feasibility to identify genetic markers linked QTL in dairy cattle. The study reveals that the application of selective DNA pooling in dairy cattle can be best exploited in the genome-wide detection of linked loci with small and large QTL effects and applied to a moderately sized half-sib family of about 500 animals
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