Ligand-binding activity of growth hormone receptor (GH-R) in bulls of different breeds with identified GH-R genotypes
2002
Grochowska, R. (Polish Academy of Sciences, Jastrzebiec (Poland). Inst. of Genetics and Animal Breeding) | Gajewska, A. | Snochowski, M. (Polish Academy of Science, Jablonna (Poland). The Kielanowski Institute of Animal Physiology and Nutrition) | Zwierzchowski, L.
The results showed significant differences in the liver GH-R Bmax (GH-R - growth hormone receptor, Bmax - receptor binding capacity) and Kd (Kd - dissociation constant) between the dairy and beef breeds. Bmax was greater in Polish Friesians as compared to the beef breeds, while Kd revealed the lowest figure in the dairy breed. No significant differences were found in the Bmax and Kd values between genotypes within the 5' flanking region of bovine GH-R gene. In conclusion, ligand-binding activity of the liver GH receptors was shown to differ between the dairy and beef bulls. Furthemore, the polymorphism in the 5' regions of GH-R gene seems to have no influence on ligand-binding properties of the liver GH receptor in cattle
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