Synthesis, structure and antibacterial activity of Cu(II) and Fe(III) complexes with pyridoxal semi-, thiosemi- and isothiosemicarbazone
2002
Jevtovic, V.S.
The thesis describes the syntheses, physico-chemical, structural and antibacterial characteristics of Cu(II) and Fe(III) complexes with pyridoxal semi-, thiosemi- and S-methylisothiosemicarbazones. The results of the syntheses was 5 new ligand forms and 24 complexes, of which 10 were characterized by X-ray structural analysis. Depending of the pH, all three ligands can be coordinated either as neutral, monoanion, or dianion, using ONO, ONS and ONN set of donor atoms, respectively, whereby the neutral and monoanionic forms of the ligands exist in the form of zwitter-ions. All three ligands form with Cu(II), irrespective of the stoichiometry Cu: ligand, give mono(ligand) complexes of square-planar and/or square-pyramidal configuration and with iron mono- and bis(ligand) octahedral complexes. The tetra-, penta- and hexa-coordinations with mono(ligand) complexes, in addition to one chelate ligand molecule, involve also the corresponding number of monodentate ligands (acid residues, H2O, NH3), and with the desolvated Cu(II) complexes dimerization of the tridentate complex. The Cu(II) complexes, as well as thiosemicarbazone itself exhibited significant activity with respect to the cyanobacter strain Microcystis, whereas only the complex of CuCl2 with thiosemicarbazone showed somewhat lower activity with respect to some gram positive bacteria.
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