A somatostatin analogue octreotide inhibits pituitary ACTH cells in rat males
2003
Milosevic, V. (Institute of Biological Research "Sinisa Stankovic", Belgrade (Serbia and Montenegro)) | Manojlovic, M. | Kostic, N. | Brkic, B. | Velkovski, S. | Sosic-Jurjevic, B. | Trifunovic, S. | Starcevic, V.
In present study, we have investigated the effects of Octreotide, a somatostain analogue given intracerebroventricularly (i.c.v.) in low doses, on morphometric characteristics of pituitary adrenocorticotropes (ACTH cells) in adult Wistar rat males. Body weight, as well as absolute and relative pituitary weights were not significantly changed in comparison with the corresponding controls (p0.05). The characteristics of immunohistochemically labelled ACTH cells in intact rat males were as follows: localization between the capillaries, stellate in shape with the cytoplasmatic processes among neighbouring cells. The nucleus follows the shape of the cell body. Small specific secretory granules were distributed mainly at the periphery of the cytoplasm. The shape, and localization of ACTH immunoreactive cells in Octreotide-treated animals were not significantly changed in comparison with the controls. Octreotide treatment significantly decreased all morphometric parameters measured, i.e. volume of ACTH cells and their nuclei by 44% and 18%, respectively, as compared to the controls (p0.05). Volume densities were also significantly decreased (by 31%; p0.05) comparing to the corresponding controls. These results indicate that Octreotide applied i.c.v. exerts a significant inhibitory effect on the immunohistochemical and morphometric characteristics of ACTH cells in rat males.
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