Plasma - protein binding of berenil in black bengal goats
2000
Mallick, T.K. | Sardar, K.K. | Parija, M.B. | Misra, S.N. (Orissa University of Agriculture and Technology, Bhubaneswar (India). Deptt. of Pharmacology and Toxicology)
Berenil (diminazene diaceturate) is used extensively to combat trypanosomiosis and babesiosis in cattle, buffalo, sheep and several other domestic animals. The drug contains strongly basic groups which bind the kinetoplast DNA by non-intercalative interaction in the parasite. Although information available on the interaction of Berenil with proteins is scanty, speculations have been made that berenil enhance protein synthesis in liver and inhibits enzymes involved in phosphorylation and drug detoxification. A recent report shows that the trypanocidal drug binds irreversibly to blood proteins of rabbit. Berenil being the drug of choice for the treatment of trypanosomiosis and babesiosis in domestic animals, a knowledge of the free drug concentration is essential to determine the therapeutic efficacy of the drug. In this investigation, we have studied the binding of goat plasma to various concentrations of Berenil in order to determine the per cent binding and to see whether the binding is plasma concentration dependent.
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